Urine Proteine Diagnostics (Nephrology)

Electrophoresis of urinary proteins (also known as SDS-PAGE or Disc-electrophoresis) is a golden standard in identification of proteins in the urine.

Through separation and detection of urinary proteins, early diagnosis of glomerular and / or tubular renal diseases can be made. In addition, urine protein electrophoresis is used to monitor progression of kidney diseases and the function of kidney transplant.

This method enables identification of paraproteins (Bence-Jones protein), appearing in the urine as a result of multiple myeloma. More precise diagnostics of paraproteinemia can be further done through additional tests, i.e. immunofixation.

UFO-technology for stain-free, digital analytics

Until now, this method was dependent on visible staining of the proteins in the gel. This time-consuming laboratory technique also had a strongly limited sensitivity.

NH DyeAGNOSTICS has developed its patented UFO-technology for identification of urine proteins. The UFO-technology implies the use of special protein-binding fluorescent dyes and fluorescent control proteins.

After a short preparation step and subsequent protein separation, proteins can be instantly digitally visualized, identified according to their size, and quantified. The ORCA Analyzer conducts these steps automatically within just seconds, the researcher can access the report independently of his / her location.

Great alternative to PhastSystem

The ORCA System consists of UFO-kit, containing precasted gels, fluorescent markers and control proteins; ORCA electrophoresis unit and ORCA Analyzer. As a modern alternative to other detection systems (i.e., PhastSystem) it is now widely used in multiple routine medical laboratories.

.

.

.